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He pānga nui tō te homoni progesterone i roto i ngā kararehe. Ka taea e te progesterone te whakatairanga i te pakeketanga o ngā whekau ira tangata me te putanga mai o ngā āhuatanga ira tangata tuarua i roto i ngā kararehe uwha, me te pupuri i te hiahia ira tangata me ngā mahi whakaputa uri noa. He maha ngā wā ka whakamahia te progesterone i roto i te mahi ahuwhenua kararehe hei whakatairanga i te estrus me te whakaputa uri i roto i ngā kararehe hei whakapai ake i te whai huatanga ohaoha. Heoi, ko te whakamahi kino i ngā homoni steroid pēnei i te progesterone ka arahi ki te mahi ate rerekē, ā, ka taea e ngā steroids anabolic te whakaputa i ngā pānga kino pēnei i te toto toto tiketike me te mate ngakau i roto i ngā kaitākaro.